Antibiotic Prophylaxis for Urinary Tract Infection–Related Renal Scarring: A Systematic Review

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Antibiotic Prophylaxis for Urinary Tract Infection-Related Renal Scarring: A Systematic Review.

CONTEXT Acute pyelonephritis may result in renal scarring. Recent prospective studies have shown a small benefit of antibiotic prophylaxis in preventing symptomatic and febrile urinary tract infections (UTIs), while being underpowered to detect any influence in prevention of renal damage. OBJECTIVES Review of the literature and a meta-analysis to evaluate the effect of antibiotic prophylaxis ...

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Antibiotic prophylaxis for urinary tract infections in renal transplant recipients: a systematic review and meta-analysis.

Urinary tract infection (UTI) is the most common bacterial infection in renal transplant recipients. To date there are no guidelines on antibiotic prophylaxis for UTI in this population. We conducted a systematic review and meta-analysis of randomized controlled trials comparing antibiotic prophylaxis vs. placebo, no intervention, or different antibiotics, all beginning postoperatively and cont...

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Non-Antibiotic Prophylaxis for Urinary Tract Infections

Increasing antimicrobial resistance has stimulated interest in non-antibiotic prophylaxis of recurrent urinary tract infections (UTIs). Well-known steps in the pathogenesis of UTIs are urogenital colonization and adherence of uropathogens to uroepithelial cell receptors. To prevent colonization in postmenopausal women, vaginal, but not oral, estrogens have been shown to restore the vagina lacto...

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Risk Factors for Recurrent Urinary Tract Infection and Renal Scarring.

OBJECTIVES To identify risk factors for recurrent urinary tract infection (UTI) and renal scarring in children who have had 1 or 2 febrile or symptomatic UTIs and received no antimicrobial prophylaxis. METHODS This 2-year, multisite prospective cohort study included 305 children aged 2 to 71 months with vesicoureteral reflux (VUR) receiving placebo in the RIVUR (Randomized Intervention for Ve...

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Antibiotic prophylaxis for urinary tract infections in antenatal hydronephrosis.

BACKGROUND AND OBJECTIVE Continuous antibiotic prophylaxis (CAP) is recommended to prevent urinary tract infections (UTIs) in newborns with antenatal hydronephrosis (HN). However, there is a paucity of high-level evidence supporting this practice. The goal of this study was to conduct a systematic evaluation to determine the value of CAP in reducing the rate of UTIs in this patient population. ...

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ژورنال

عنوان ژورنال: Pediatrics

سال: 2017

ISSN: 0031-4005,1098-4275

DOI: 10.1542/peds.2016-3145